Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
Fournier SB, D'Errico JN, Adler DS, Kollontzi S, Goedken MJ, Fabris L, Yurkow EJ, Stapleton PA (2020). Particle and Fibre Toxicology.
What they found
Pregnant rats had 20 nm fluorescent polystyrene beads placed in their lungs late in pregnancy. Within 24 hours the particles were found in the placenta and fetal tissues, and fetal and placental weights were 7% and 8% lower than controls.
- Sample
- Pregnant Sprague Dawley rats, plus isolated placenta perfusion
- What it can't tell you
- A single, very large dose (2.64 × 10^14 particles) of pristine nanoparticles delivered directly into the airway, unlike real inhalation. Rats, not humans. Short (24-hour) follow-up.
- Funding
- US National Institute of Environmental Health Sciences (R00-ES024783), Rutgers Center for Environmental Exposures and Disease (P30-ES005022) and Rutgers toxicology training grant (T32-ES007148); no competing interests
- Topics
- Health effects, Baby and kids
- Checked against
- Abstract (Europe PMC, PMID 33099312, PMC7585297); funder via Crossref